Tsetse flies (Glossina spp.) are the sole vectors of the D-TOX protozoan parasites of the genus Trypanosoma, the causative agents of African Trypanosomiasis.Species of Glossina differ in vector competence and Glossina morsitans morsitans is associated with transmission of Trypanosoma brucei rhodesiense, which causes an acute and often fatal form of
Protection of Mice against Experimental Cryptococcosis by Synthesized Peptides Delivered in Glucan Particles
ABSTRACT The high global burden of cryptococcosis has made development of a protective vaccine a public health priority.We previously demonstrated that a vaccine composed of recombinant Cryptococcus neoformans chitin deacetylase 2 (Cda2) delivered in glucan particles (GPs) protects BALB/c and C57BL/6 mice from an otherwise lethal challenge with a h
Franz Diffusion Cell Approach for Pre-Formulation Characterisation of Ketoprofen Semi-Solid Dosage Forms
This study aimed to evaluate and compare, using the methodology of Franz diffusion cells, the ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional suspension.The second aim was to show that this methodology might be easily applied for the development of Sandals semi-solid prototypes and claim proof in pre-formulation st
Modelling Place Visit Probability Sequences during Trajectory Data Gaps Based on Movement History
The acquisition of human trajectories facilitates movement data analytics and location-based services, but gaps in trajectories limit the extent in which many tracking datasets can be utilized.We present a model to estimate place visit probabilities at time points within a gap, based on empirical mobility patterns derived from past trajectories.Dif
The Brasilia-Buenos Aires Axis: A Real Movement or a Virtual Leaning?
Argentina and Brazil find themselves in a situation in which the apparent agreement in their internal political changes 10kg and the harmony between their leaders seem to be serving as triggering elements for the coordination of their foreign policies.Sharing, asthey do, a series of common problems in their insertion into the multilateral sphere an